Bowler Laboratory
Russell Bowler, M.D., Ph.D. obtained a B.S. in mathematical and computational sciences from Stanford University, a M.D. from the University of California at San Francisco (UCSF), and a Ph.D. in Cell and Developmental Biology from the University of Colorado (CU). He completed his internal medicine residency at UCSF and a pulmonary and critical care fellowship from CU.
The mission of our lab is to understand the mechanisms of how inhaled smoke (cigarette or cannabis smoke and vaping) leads to the development of chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States. We have generated genetic, genomic, metabolic profiles on 10,000 subjects in the NIH sponsored COPDGene and SPIROMICS cohort and use these Omics data to identify novel diagnostic and therapeutic targets. Our laboratory also uses mouse models to study the mechanisms of smoke induced lung disease. We also use wearable sensors and artificial intelligence/machine learning to develop algorithms for at-home detection of COPD exacerbations.
Lab Resources and Services
The Bowler Laboratory offers high-throughput genomic, proteomic, and metabolic profiling. Additionally, oxidative stress, antioxidant measurements, and translational models in COPD (cigarette smoke extract, whole smoke).
Current Projects
- GWAS, Genome, Metabolome and proteome profiles of emphysema and airway disease
- Cigarette smoke induces endogenous oxidant injury
- Vaping effects on young adults
- Using wearable sensors and AI/ML to detect COPD exacerbations while at home
- New biologic therapy for COPD
Currently Enrolling Research Projects
- Study of people ages 30-55 who have smoked tobacco cigarettes: NIH SOURCE study: https://sourcestudy.net/source/clinicalSites/National%20Jewish%20Health
- Study of people who vape ages 18-25: click here; contact Engel Elena <engele@njhealth.org>
- Study of people with COPD and two exacerbations in the past year: email "Maria Saucedo Garcia," <SAUCEDOGARCIAM@njhealth.org>
- Study of people with COPD with a history of one exacerbation who want to use wearable sensors such as an Apple Watch: contact contact Engel Elena <engele@njhealth.org>
Russell P. Bowler, MD, PhD