Gorska Laboratory

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Publications

  1. Verma M, Michalec L, Sripada A, McKay J, Sirohi K, Verma D, Sheth D, Martin R, Dyjack N, Seibold MA, Knapp JR, Tu TH, O'Connor BP, Gorska MM, Alam R. The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. J Exp Med. 2021 Jul 5;218(7):e20201354. Epub 2021 Jun 2. PMID: 34076685; PMCID: PMC8176441. 

  2. Sripada A, Sirohi K, Michalec L, Guo L, McKay JT, Yadav S, Verma M, Good J, Rollins D, Gorska MM, Alam R. Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLoS Biol. 2021 Mar 8;19(3):e3001063. doi: 10.1371/journal.pbio.3001063. PMID: 33684096; PMCID: PMC7971865.

  3. Qian Q, Paul Chowdhury B, Sun Z, Lenberg J, Alam R, Vivier E, Gorska MM. Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.  J. Clin. Invest. 2020; 130:4133-4151. PMID: 32407293; PMCID: PMC7410053.

  4. Liu S, Sirohi K, Verma M, McKay J, Michalec L, Sripada A, Danhorn T, Rollins D, Good J, Gorska MM, Martin RJ, Alam R. Optimal identification of human conventional and nonconventional (CRTH2-IL7Rα-) ILC2s using additional surface markers. J. Allergy Clin. Immunol. 2020; 146:390-405. PMID: 32032632; PMCID: PMC7398840. 

  5. Verma M, Liu S, Michalec L, Sripada A, Gorska MM, Alam R. Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9(+) and IL-13(+) type 2 innate lymphoid cell subpopulations. J. Allergy Clin. Immunol. 2018; 142:793-803.e8. PMID: 29132961

  6. Lenberg J, Qian Q, Sun Z, Alam R, Gorska MM. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A. J. Allergy Clin. Immunol. 2018; 141:1118-1122.e3. PMID: 28943469

  7. Gorska MM. Mouse Models of Asthma. Methods Mol. Biol. 2018; 1809:351-362. PMID: 29987800.

  8. Liu S, Verma M, Michalec L, Liu W, Sripada A, Rollins D, Good J, Ito Y, Chu H, Gorska MM, Martin RJ, Alam R. Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin. J. Allergy Clin. Immunol. 2018; 141:257-268.e6. PMID: 28433687

  9. Liu W, Liu S, Verma M, Zafar I, Good JT, Rollins D, Groshong S, Gorska MM, Martin RJ, Alam R. Mechanism ofT(H)2/T(H)17-predominant and neutrophilic T(H)2/T(H)17-low subtypes of asthma. J. Allergy Clin. Immunol. 2017; 139:1548-1558.e4. PMID: 27702673; PMCID: PMC5376378.

  10. Gorska MM. Natural killer cells in asthma. Curr. Opin. Allergy Clin. Immunol. 2017; 17:50-54. PMID: 27841766; PMCID: PMC5495007. 

  11. Christianson CA, Goplen NP, Zafar I, Irvin C, Good JT Jr, Rollins DR, Gorentla B, Liu W, Gorska MM, Chu H, Martin RJ, Alam R. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J. Allergy Clin. Immunol. 2015, 136:59-68. PMID: 25617223.

  12. Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, Martin RJ, Alam R. Increased frequency of dual-positive T(H)2/T(H)17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J. Allergy Clin. Immunol. 2014, 134:1175-1186. PMID: 25042748.

  13. Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J. Allergy Clin. Immunol. 2014, 134:63-72. PMID: 24365139.

  14. Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R. Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J. Immunol. 2013, 190:159-167. PMID: 23225884.

  15. Gorska MM, Alam R. Consequences of a Mutation in the UNC119 Gene for T Cell Function in Idiopathic CD4 Lymphopenia. Curr. Allergy Asthma Rep. 2012, 12:396-401. PMID: 22729960.

  16. Goplen N, Karim Z, Guo L, Zhuang Y, Huang H, Gorska MM, Gelfand E, Pagés G, Pouysségur J, Alam R. ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J. 2012, 26:1934-1945. PMID:22262639.

  17. Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012, 119:1399-1406. PMID: 22184408.

  18. Alam R, Gorska MM. MAPK Signaling and ERK1/2 bistability in asthma. Clin. Exp. Allergy. 2011, 41:149-159. PMID: 21121982.

  19. Liang Q, Guo L, Gogate S, Karim Z, Hanifi A, Leung DY, Gorska MM, Alam R. IL-2 and IL-4 Stimulate MEK1 Expression and Contribute to T Cell Resistance against Suppression by TGF-{beta} and IL-10 in Asthma. J. Immunol. 2010, 185: 5704-5713. PMID: 20926789.

  20. Liu W, Tundwal K, Liang Q, Goplen N, Rozario S, Quayum N, Gorska MM, Wenzel S, Balzar S, Alam R. Establishment of ERK1/2 Bistability and Sustained Activation through Sprouty 2 and its Relevance for Epithelial Function. Mol Cell Biol. 2010, 30:1783-1799. PMID: 20123980.

  21. Karim ZM, Vepachedu R, Gorska MM, Alam R.  Unc119 inhibits dynamin and dynamin-dependent endocytic processes.  Cell. Signal. 2010, 22: 128-137. PMID: 19781630.

  22. Gorska MM, Goplen N, Liang Q, Alam R. Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. J. Immunol. 2010, 184:4488-4496. PMID: 20220094.

  23. Goplen N, Karim Z, Liang Q, Gorska MM, Rosario S, Guo L, Alam R. Combined Sensitization of Mice to Extracts of Dust Mites, Ragweed and Aspergillus Breaks through Tolerance and Establishes Chronic Features of Asthma in Mice. J. Allergy Clin. Immunol. 2009, 123: 925-932. PMID: 19348928.

  24. Gorska MM, Liang Q, Karim Z, Alam R. Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. J. Immunol. 2009, 183: 1675-1684. PMID: 19592652.

  25. Liu W, Liang Q, Balzar S, Wenzel S, Gorska MM, and Alam, R. Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways. J. Allergy Clin. Immunol. 2008, 121: 893-902. PMID: 18395552.

  26. Goplen N, Gorska MM, Stafford SJ, Rosario S, Guo L, Liang Q, and Alam R.  A Phospho-site Screen Identifies Autocrine TGF beta-driven Activation of Protein Kinase R as a Survival-limiting Factor For Eosinophils. J. Immunol. 2008, 180: 4256-4264. PMID: 18322238.

  27. Vepachedu R, Gorska MM, Singhania N, Alam R. Unc119 regulates myofibroblast transformation through the activation of Fyn and p38 MAPK pathway. J. Immunol. 2007, 179:682-690. PMID: 17579091.

  28. Gorska MM, Stafford S, Liang Q, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R. MK2 controls the level of negative feedback in the NFkB pathway and is essential for endothelial permeability and airway inflammation. J. Exp. Med. 2007, 204:1637-1652. PMID: 17576778.

  29. Gorska-Ciebiada, M, Ciebiada M, Gorska MM, Gorski P, Grzelewska-Rzymowska I. Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity. Ann. Allergy Asthma Immunol. 2006, 97:66-72. PMID: 16892784.

  30. Gorska MM, Cen O, Liang Q, Stafford SJ, Alam R. Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. J. Biol. Chem. 2006, 281:14429-31449. PMID: 16556602.

  31. Gorska MM, Alam R. The signaling mechanism of eosinophil activation. Expert Rev. of Clin. Immunol. 2005, 1:247-256, PMID: 20476938.

  32. Gorska MM, Stafford SJ, Cen O, Sur S, and Alam R. Unc119, a Novel Activator of Lck/Fyn, is Essential for T Cell Activation. J. Exp. Med. 2004, 199:369-379. PMID: 14757743.

  33. Gorska, MM, Alam R. Signaling molecules as therapeutic targets in allergic diseases. J. Allergy Clin. Immunol. 2003, 112:241-250. PMID: 12897726.

  34. Alam R, Gorska MM. 3. Lymphocytes. J. Allergy Clin. Immunol. 2003, 111:S476-S485 PMID: 12592294.

  35. Cen O, Gorska MM, Stafford, SJ, Sur, S, Alam, R. Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J. Biol. Chem. 2003, 278:8837-8845. PMID: 12496276.

  36. Alam R, Gorska MM. Genomic Microarrays. Arraying Order in Biological Chaos? Am. J. Respir. Cell Mol. Biol. 2001, 25:405-408. PMID: 11694444.

  37. Gorska MM, Kowalski ML. Gene knock-out technology - application in experimental medical research. Allergy, Asthma, Immunology-Clinical Review. 1997, 2:162-169 (in Polish).

  38. Woszczek G, Borowiec M, Mis M, Gorska MM, Kowalski ML. Comparison of serological and molecular (PCR-SSP) techniques of HLA DR typing in clinical laboratory routine. Ann. Transpl. 1997, 2:39-42. PMID: 9869840.

View Dr. Gorska's Bibliography at NCBI

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