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XTMAB-16: A New Drug to Reduce Steroid Use in Sarcoidosis
People with pulmonary sarcoidosis usually rely on corticosteroids to help manage symptoms. Researchers are investigating the safety of a new study drug called XTMAB-16 to see if it can help reduce corticosteroid use while treating the disease.
Effects of Keto Diet in People with HFpEF
The keto diet has helped many people lose weight and improve their overall health. Researchers are investigating if it can also benefit people with a specific type of heart failure.
Possible New Treatment for CF and NTM
Researchers in the ABATE Study are testing the safety of a drug called gallium nitrate for people with cystic fibrosis (CF) who also have been diagnosed with nontuberculous mycobacteria (NTM).
ENCORE Study for NTM
In the ENCORE study, researchers are evaluating the effectiveness and safety profile of a study medication on people who have been diagnosed with Nontuberculous Mycobacterial (NTM) lung infection caused by Mycobacterium avium complex (MAC).
Determining How Parenthood Affects Cystic Fibrosis Patients
Surveys have shown that a growing number of cystic fibrosis (CF) patients are considering parenthood, so steps should be taken to better understand the effects of parenthood on CF patients in order to more effectively support them.
EFZO-Fit Trial for Pulmonary Sarcoidosis
Researchers want to understand if an investigational medication called efzofitimod is safe, effective and tolerated by people with pulmonary sarcoidosis in the EFZO-Fit trial.
Potential New Treatment for Metastatic Lung Cancer
Researchers want to know if an investigational drug called SAR408701 is better than docetaxel, a chemotherapy drug already approved to treat non-small cell lung cancer (NSCLC) patients with CEACAM 5 positive tumors. The goal of this study is to determine if SAR408701 improves survival rate for NSCLC patients.
Assessing a New Investigational Enzyme Replacement Therapy in CF Patients with EPI
Researchers want to know if an investigational oral treatment called ANG003 is safe and to evaluate its effects on nutrient absorption.
IMPAHCT Study Investigates a New Treatment for Pulmonary Hypertension
The IMPAHCT clinical trial is evaluating an investigational medication for pulmonary arterial hypertension (PAH) called AV-101 to find out what dose is safe and tolerable, and works best in people with PAH.
BBT-877: Possible Treatment for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) currently affects millions of people globally, and current treatments such as pirfenidone or nintedanib are often poorly tolerated in some patients due to frequently associated side effects. Researchers want to know if an investigational medication called BBT-877, either alone or in conjunction with other therapies, may help slow lung function decline.
Treating Deployment-Related Asthma with Supplements
Many people returning from military deployment have developed asthma as a result of inhaling hazardous materials. Exposures to diesel, burn pits, biomass smoke and sandstorms during deployment likely play a role. Some people with deployment-related asthma do not respond well to standard asthma medications.
BEACON-CF: Investigational mRNA Therapy for Cystic Fibrosis
For many people living with cystic fibrosis, there are treatments available called cystic fibrosis transmembrane conductance regulator (CFTR) modulators that can help treat the underlying cause of cystic fibrosis. However, more than 5,000 people living with cystic fibrosis have a change in both of their CFTR genes that makes them not expected to benefit from CFTR modulators.
SUNRISE Trial for Oral Steroid Dependent Asthma
People with severe asthma are often dependent on oral corticosteroids, such as prednisone, to treat their condition. Researchers are currently investigating whether a new biologic treatment called tezepelumab may help to reduce or remove the need for these steroid medications.
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Extensive Stage Small Cell Lung Cancer Combination Treatment
Determine the efficacy and safety of lurbinectedin (a type of chemotherapy) when combined with atezolizumab (an immunotherapy treatment) as a maintenance treatment for those with ES-SCLC.
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PRA023 for Systemic Sclerosis with Interstitial Lung Disease
Researchers are studying a new medication called PRA023 that has anti-inflammatory and antifibrotic properties to determine how well it works against systemic sclerosis (SSc) with interstitial lung disease (ILD).
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MyAI Registry for People with Adrenal Insufficiency
To help better understand adrenal insufficiency (AI) and its progression, researchers have developed a new registry called MyAI.
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IPF COMFORT Study for Chronic Cough
The IPF COMFORT Study is a clinical research study in patients with coughing attributed to Idiopathic Pulmonary Fibrosis.
Lung Cancer & COVID Infection
Researchers want to understand how the body of a person with active lung cancer responds to COVID-19, should they contract the virus.
Blood Test to Help Identify Cancer
Researchers want to learn if a blood test can be used to identify cancers in adults. Current or former smokers who have been diagnosed with cancer but haven’t started treatment are needed for this trial. Participants will receive a blood draw and review of their medical history with a research coordinator.
OCEAN Study for EGPA
People with eosinophilic granulomatosis with polyangiitis (EGPA) are needed for the OCEAN clinical trial. The study compares two medications: mepolizumab (NUCALA), which is administered by an injection once a month, and depemokimab, an investigational medication that is injected twice a year.
Investigational Gene Therapy for Adults with CF
Adults with Cystic Fibrosis who are unable to take CFTR modulators are being asked to participate in a clinical trial for an investigational gene therapy drug known as 4D-710.
Predict and Prevent Lung Disease
Researchers are asking healthy adults, 25-35 years old, to join a five-year study exploring factors that may affect lung health with the goal of understanding lung disease.
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Effects of Pregnancy for Cystic Fibrosis Patients
If you are a pregnant with cystic fibrosis, consider participating in this trial to learn how pregnancy affects your health.
Adults with Cystic Fibrosis (CF) & Exercise Intolerance
This exercise study is investigating how an already FDA approved drug for treatment of pulmonary vascular disease, sildenafil (Revatio ®), impacts exercise tolerance and capacity in people with cystic fibrosis (CF).
SEAL Study: Stopping Eczema and Allergy
Can allergies be prevented in infants? Researchers want to know if keeping a baby’s skin healthy and hydrated with moisturizer will prevent the child from developing allergies such as food allergies. Learn how you and your child can help researchers.
Healthy People Needed for Sarcoidosis Research
Researchers are working to understand the different ways sarcoidosis, a disease that causes scarring in the lungs, develops.
Skin, Airway & Esophageal Epithelial Barriers in Youth
Researchers want to better understand if the causes of asthma, eczema, food allergies, eosinophilic esophagitis and GERD can be determined at a cellular level.
Biomarkers & Hypersensitivity Pneumonitis Progression
Are biomarkers in the blood of patients with hypersensitivity pneumonitis (HP) predictive? Researchers understand if biomarkers can help doctors understand how quickly the disease will progress
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SUNBEAM: Studying Allergy Development in Babies
Why do babies develop food allergies and eczema? Researchers are studying factors before birth and through age 3 that may influence the development of allergic conditions.
CHARM Study for Asthma
Researchers want to improve medical care for asthmatics with new mobile health technologies. Study participants will use at-home technologies to track and record health data and participate in surveys and questionnaires about their health.
Skin Reactions to Cancer Immunotherapy
Adults with cancer who are receiving immunotherapy are needed for a new research study to understand how immunotherapy changes the body’s immune response leading to skin reactions.
Understanding Allergy Development in Infants
Researchers want to know what causes food allergies, eczema and wheezing in infants. If you’re pregnant, you may be able to help find the answer.
Can Pembrolizumab (MK3475) with SBRT Treatment Stop or Slow Non-Small Cell Lung Cancer?
Patients with medically inoperable stage I/IIA non-small cell lung cancer (NSCLC) who have not received prior anticancer therapy for lung cancer, may qualify for a clinical trial investigating if the combination of pembrolizumab (MK-3475) and Stereotactic Body Radiation Therapy (SBRT) may help stop or slow a relapse of NSCLC compared to SBRT alone.
Silicosis Registry
If you’ve been exposed to silica dust, like stone and concrete, you may have developed a silica-related disease. National Jewish Health is creating a registry for silicosis and related diseases in order to better understand their risk factors and prevention.
Predicting ILD from Hypersensitivity Pneumonitis
Anyone with hypersensitivity pneumonitis may qualify for this observational study and help researchers find patterns for predicting ILD.
Atopic Dermatitis & Skin Infections
National Jewish Health researchers are trying to determine why people with atopic dermatitis or eczema are more susceptible to bacterial infections. Learn how you can participate in our research study.
Identifying Characteristics and Patterns of Asthma
Our researchers are working to identify the clinical, physiologic, genetic and molecular characteristics of asthmatics.
New Trial Medication for Pulmonary Arterial Hypertension
By adding a new investigational Pulmonary Arterial Hypertension (PAH) medication to your current therapy, you could experience relaxed and widened artery walls.
Healthy Adults Needed for Beryllium Disease Study
By participating in our study, you can help forward research on lung disease. Our researchers are hoping to learn more about the blood cells involved in the development of scarring lung diseases and create new treatment therapies.
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Lung Injury from Military Deployment
The purpose of this study is to learn more about lung disease found in contractors and U.S. military personnel serving in Iraq and Afghanistan after September 11, 2001.
Link Between Rheumatoid Arthritis & Lung Disease
Our researchers are trying to understand the connection, as well as how to prevent and treat lung disease in RA patients.
ILD & Early Rheumatoid Arthritis
Our researchers are trying to understand how interstitial lung disease (ILD) develops in people with rheumatoid arthritis (RA), and how it may impact their quality of life.
Idiopathic Pulmonary Fibrosis (IPF) & GERD
The purpose of this study is to measure and accurately identify the presence and severity of gastroesphageal reflux disease (GERD), commonly called acid reflux, in idiopathic pulmonary fibrosis (IPF) patients using the Supraglottic Index (SGI).
Immune Pathways & Development of Sarcoidosis
If you are an adult with sarcoidosis who is not on immunosuppressive therapy, you may be able to help our researchers learn more about different types of sarcoidosis and how it develops.
Pulmonary Fibrosis & Genetic Factors
The purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis.
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ADRN-12/LEADS (Longitudinal Endotyping of Atopic Dermatitis Through Transcriptomic Skin Analysis)
Eczema (atopic dermatitis) is typically classified as mild, moderate or severe. In this trial, researchers are studying gene expression for the varying severity levels of eczema in order to guide new and improved treatments strategies and more personalized treatments.
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NICE-CF: Colon Cancer Screening for adults with Cystic Fibrosis
Adults with cystic fibrosis (CF) are at a higher risk of developing colon cancer due to a mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene..
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Understanding Skin Problems from Eczema and Food Allergies
Researchers are studying the differences in the skin and immune cells of people with food allergies and eczema, and those without.
Testing Blood’s Response to Foreign Substances
Researchers are conducting a study of how human blood cells work. Their goal is to examine how these cells respond to different bacteria and other foreign substances.
Pulmonary Arterial Hypertension & increased dose of Opsumit
The UNISUS study will compare the effectiveness and safety of a higher dose of an investigational medication called Opsumit to a lower dose in people with pulmonary arterial hypertension (PAH). The results of the UNISUS Study will provide more information about the investigational medication’s effectiveness and safety when it is given as a higher dose to adults with PAH.