Hypersensitivity Pneumonitis: Symptoms Make an Appointment Ask a Question Search Conditions This information was reviewed and approved by Cecile S. Rose, MD, MPH (7/1/2012). Symptoms of brief or severe (acute) hypersensitivity pneumonitis often occur 6-8 hours after exposure to the foreign substance.Symptoms may include:chills,fever,cough, andshortness of breath.Symptoms of long-lasting (chronic) HP include:gradual onset of shortness of breath (especially with activity),cough,unusual fatigue,loss of appetite, andunintentional weight loss. Clinical Trials Atopic Dermatitis & Skin Infections Understanding Allergy Development in Infants