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Pulmonary Arterial Hypertension & increased dose of Opsumit

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Trial Objectives


The UNISUS study will compare the effectiveness and safety of a higher dose of an investigational medication called Opsumit to a lower dose in people with pulmonary arterial hypertension (PAH). The results of the UNISUS Study will provide more information about the investigational medication’s effectiveness and safety when it is given as a higher dose to adults with PAH. Participants will be randomly assigned to receive a tablet of 10 mg or 75 mg dose of Opsumit to take once a day. During clinic visits, participants may have their vital signs taken, provide a blood sample and perform a walking test.

Who Can Participate


Patients diagnosed with pulmonary arterial hypertension

Age: 18+ Gender Any

Estimated Time Commitment


Up to 4 years. Year 1: monthly visits. Year 2: Visits every three months. Years 3-4: visits every six months.

Payment & Reimbursement


Payment Provided

Travel Reimbursement Available

Trial Contact


For more information, contact:

Jennifer Underwood
303.398.1518

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Trial Location


National Jewish Main Campus, Denver, CO

Principal Investigators

Mohammad Dalabih

Mohammad Dalabih, MD

Co-Investigators

  • Marjorie Patricia George

    Marjorie Patricia George, MD

  • Vera Pillitteri

    Vera Pillitteri, DNP, FNP-BC

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