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PrecISE Severe Asthma Interventions

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Trial Objectives

The purpose of this study is to understand how to treat different types of severe asthma using precision medicine. Precision medicine is an approach that targets treatments to defined subgroups of patients who share similar characteristics. For example, patients who have a certain genetic variation or patients with high number of blood eosinophils. Study participants will receive several treatments based on their type of severe asthma for research purposes.

Who Can Participate

Individuals 12 years of age and older whose asthma symptoms are not well-controlled on high dose of inhaled corticosteroids, including those who have frequent asthma attacks.

Age: 12+ Gender Any

Estimated Time Commitment

3 phases, approximately 9 visits per phase for up to 2 years

Payment & Reimbursement

Payment Provided

Travel Reimbursement Not Available

Trial Contact

For more information, contact:

Allen Stevens


Michael White

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Trial Location

National Jewish Main Campus, Denver, CO

Trial Sponsors

National Institutes of Health

Principal Investigators

Michael E. Wechsler

Michael E. Wechsler, MD, MMSc


  • Rafeul Alam

    Rafeul Alam, MD, PhD

  • Ronina A. Covar

    Ronina A. Covar, MD

  • Vamsi P. Guntur

    Vamsi P. Guntur, MD, MSc

  • Laurie A. Manka

    Laurie A. Manka, MD

  • Pamela L. Zeitlin

    Pamela L. Zeitlin, MD, MPhil, PhD

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