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Does Keto Diet Help Reverse Heart Failure with Preserved Ejection Fraction?

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Trial Objectives


The purpose of this study is to learn if a low carbohydrate ketogenic diet, or keto diet, can treat obesity-related heart failure with preserved ejection fraction (HFpEF). Studies have shown that weight loss through gastric bypass and calorie restriction can improve heart function. To see if a low carbohydrate diet works similarly, participants will follow a keto diet and be monitored for seven months.

Who Can Participate


  • Adults age 21-80 who meet clinical signs and symptoms of heart failure
  • Patients who received a right heart catheterization (RHC) and cardiopulmonary exercise test within the last 6 months
  • Patients who meet abdominal obesity with BMI > 30 kg/m2 or have a waist circumference:
    • Men > 102 cm
    • Women > 88 cm
  • Patients must own and operate a smart phone or tablet with email capabilities.

Age: 21-80 Gender Any

Estimated Time Commitment


Not Specified

Payment & Reimbursement


Payment Provided

Travel Reimbursement Not Available

Trial Contact


For more information, contact:

Maria Saucedo
303.398.1790

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Trial Location


National Jewish Main Campus, Denver, CO

Trial Sponsors


Rose Community Foundation Project/Program

Principal Investigators

Darlene Kim

Darlene Kim, MD, FACC

Co-Investigators

Marjorie Patricia George

Marjorie Patricia George, MD

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